๐Ÿ”ฌ Lysis From Without

Cell-wall destruction initiated by multiple phage adsorption to individual bacteria.

by Stephen T. Abedon Ph.D. (abedon.1@osu.edu)

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About this entry: Lysis From Without is one of a growing set of phage biology and phage therapy terms defined here. For more phage terms, see Abedon, S.T. (2025). Phage Therapy Annotated Glossary. Preprints.org. 10.20944/preprints202508.0347.v1

phage.org/terms/lysis_from_without.html  ·  Abedon’s Books  ·  DOI: 10.5281/zenodo.20173633

How can I improve this page?  contact: terms@phage.org

Lysis From Without: Cell-wall destruction initiated by multiple phage adsorption to individual bacteria.

Discussion

<p>This is the definition from Adams (1959), p. 440), "Abortive infection accompanied by prompt lysis of a cell, typically following excessive multiple infection."

Consistent with this idea that lysis from without is a form of abortive infection, a number of authors have speculated that they may be observing lysis from without but with this term seemingly defined solely as bacterial death attained following presumptively high multiplicity phage adsorption, that is, without emphasizing that bacterial lysis must also occur. Lysis profile wikipedia.org/wiki/Experiment" target="_blank" class="bap-term">experiments or other means of detecting lysis can and should be used in such cases to confirm that lysis, in fact, can occur following high multiplicity adsorption by a given phage isolate to a given bacterial strain.

References: Abedon (1994) and nih.gov/pubmed/21687534" target="_blank" class="bap-term">Abedon (2011).

External links

References

  • Abedon (2011)
  • Adams (1959). Bacteriophages. Interscience Publishers, New York.
  • Abedon (1994).

How to cite this page

Abedon, S.T. (2026). Phage Terms. https://terms.phage.org  ·  10.5281/zenodo.20173633

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Lysis From Without — terms.phage.orgphage.org — Stephen T. Abedon — Version 2026.05.14